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Brensocatib has no impact on COVID-19 clinical outcomes

Brensocatib has no effect on clinical outcomes in COVID-19 | The latest news for doctors, nurses and pharmacists | Respirology

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Results from the STOP-COVID trial presented at ERS 2022 showed no clinical benefit with the dipeptidyl peptidase-1 (DPP-1) inhibitor brensocatib compared to placebo in patients hospitalized with COVID-19 in the UK. “[T]retreatment with brensocatib for 28 days was associated with worse clinical status on the WHO 7-point ordinal scale* at the end of treatment than …

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The effect of corticosteroids on mortality in hospitalized patients with COVID-19

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In a recent study published on medRxiv* prepress server, researchers evaluated the impact of modern causal inference methods in estimating the effect of corticosteroids on coronavirus disease-related mortality 2019 (COVID-19). Study: Corticosteroids in COVID-19: Optimization of observational research through target trial emulations. Image credit: luchschenF / Shutterstock Observational research has provided great opportunities to understand …

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